9th Mentored Paper (Summer 2023)

Topics

MPI9.1: What is the role of VEGF-A in influencing the epigenetic regulation of endothelial cell genes? (literature review)

 

MPI9.2: What is the role of the p53/mdm2 axis in epigenetic regulation of skeletal muscle genes? (literature review)

 

MPI9.3: How do regulatory T-cells contribute to tumorigenesis and how can they be targeted?

 

MPI9.4: How can patient response to immune checkpoint inhibitors (anti-PD1/PDL1 and anti-CTLA-4) be improved?

 

MPI9.5: What advantages do various genetic applications provide for the healthcare field?

 

MPI9.6: How can genetic testing be used to navigate chronic kidney disease?

 

MPI9.7: How might brain-heart mechanisms be mediating cardiac problems in patients who have suffered brain injury?

 

MPI9.8: Can plant-based diets be beneficial to COVID-19 related outcomes?

 

MPI9.9: What are lifestyle modifications effective for the management of Polycystic ovary syndrome (PCOS)?

 

MPI9.10: Is female reproductive health impacted during COVID-19 pandemic? What are the implications?

 

MPI9.11: What therapeutic opportunities can you see in the tumor microenvironment

 

MPI9.12: What is the potential for tumor subtyping to influence clinical practice?

 

MPI9.13: What are the origins of cancer-associated fibroblasts?

 

MPI9.14: How can nanobubbles be used/applied in your field of choice?

 

MPI9.15: How can nanotechnology help in reaching UN sustainability goals?

 

MPI9.16: What is flash graphene, and what applications can it be used in?

 

MPI9.17: Review a nanomaterial of your choice and it's impact in your field of science and the environment.

 

MPI9.18: How do epigenetic changes affect differentiation during hematopoiesis?

 

MPI9.19: How does transcription factor dysregulation result in leukemogenesis? How does this apply to pre-leukemic stem cells?

 

MPI9.20: How does the bone marrow microenvironment support leukemia? And does it play a role in measurable residual disease (MRD)?

 

MPI9.21: Bone metastases commonly occur in those with prostate cancer and breast cancer. What makes the bone a favourable site for metastatic bone disease and what therapies have been developed to mitigate some of these effects?

 

MPI9.22: Perhaps one of the most challenging tasks for scientists is developing in vitro models to describe in vivo processes. One new field of interest is microfluidics and the development of organ-on-a-chip models, what are the advantages and limitations of such models?

 

MPI9.23: Describe the first line treatments for patients with prostate cancer. What novel treatments have been developed in response to castration resistant prostate cancer?

 

MPI9.24: The use of deep learning and artificial intelligence in the detection of disease progression, specifically in bone and joint diseases

 

MPI9.25: What advances in prosthetic design have improved the quality of life of patients requiring joint replacements? (They can focus on any one joint, i.e. knee, hip, shoulder, etc.)

 

MPI9.26: How to support infant nutrition among vulnerable Canadian families?

 

MPI9.27: How to deal with missing data?

 

MPI9.28: How to lower food insecurity among Canadian university students?

 

MPI9.29: What are the current challenges and emerging solutions for severe traumatic brain injury in the intensive care unit?

 

MPI9.30: Which vaccination strategy results in the least number of deaths during a pandemic?

 

MPI9.31: What percentage of the population needs to be vaccinated to achieve herd immunity for an infectious disease?

 

MPI9.32: How does in vitro fertilization influence fetal programming and adult health?

 

MPI9.33: Can recent developments with stem cells and human organoids be applied to reproductive processes?

 

MPI9.34: Can the microbiome be used as a diagnostic tool to detect human disease?

 

MPI9.35: What are the current challenges and solutions for overweight and obesity treatment?

 

MPI9.36: Describe the landscape of prescription medications to treat overweight and obesity. How could the use of these medications influence or prevent overweight and obesity relapse?

 

MPI9.37: What role does mental health play in the prevention of treatment of overweight and obesity?

 

MPI9.38: In what extent collagen is being used in skin tissue engineering? How the existing collagen scaffolds can be optimised?

 

MPI9.39: What are the collagen-based skin substitutes that passed the clinical trial stage and are being produced in large scale?

 

MPI9.40: Were the incidence and prevalence of COVID-19 infection cases underestimated during the Omicron season?

 

MPI9.41: What affects the willingness of people to take COVID-19 vaccines?

 

MPI9.42: Did people with respiratory diseases receive a proper level of care during COVID-19?

 

MPI9.43: How has interprofessional collaboration changed after the COVID-19 pandemic amongst healthcare teams?

 

MPI9.44: Have prioritization strategies/policies for waitlists of health interventions discussed the ethical principles that underpin them?

 

MPI9.45: What criteria has been used to develop prioritization policies for waitlists of health interventions?

 

MPI9.46: How can simulation/decision models be used to assess the impact of different prioritization strategies for waitlists of health interventions?