2nd Mentored Paper Initiative (Winter 2021)

Topics

MPI2.1: What are some neural biomarkers of early Alzheimer's disease using electroencephalography (EEG)?

 

MPI2.2: What cognitive profiles distinguish dementia due to Alzheimer's disease from vascular dementia and Parkinson's dementias?

 

MPI2.3: Prior research has suggested that younger adults tend to be more "evening" people, and older adults tend to be more "morning" people. How do physiological and psychological factors change with circadian rhythms and aging?

 

MPI2.4: How does microglial depletion influence the brain's ability to repair following injury?

 

MPI2.5: What role do astrocytes play in the pathology of mild traumatic brain injury?

 

MPI2.6: What is the prevalence of symptomatic Neonatal Abstinence Syndrome among neonates exposed to maternal selective serotonin reuptake inhibitor or serotonin and norepinephrine reuptake inhibitors in-utero? (This will be a systematic review of prevalence.)

 

MPI2.7: An innumerable number of biological processes occur simultaneously in each cell, and compartmentalization of these processes is of utmost importance for their regulation. What are some of these compartments and how do they function?

 

MPI2.8: Why is yeast such a widely used eukaryotic model organism?

 

MPI2.9: How does social connectedness influence disease transmission in various species?

 

MPI2.10: How do parasites manipulate the behaviour of their hosts?

 

MPI2.11: Do non-human animals experience mental illnesses? If so, which animals and how?

 

MPI2.12: Effective health messaging has become especially important during the pandemic. How has the nature of public health messaging changed over time in different societies, and how can principles of human psychology play into crafting effective health messaging techniques?

 

MPI2.13: One of the challenges in treating brain disorders such as brain cancer is the impermeability of the blood-brain barrier to therapeutic agents. What is the reason behind this impermeability, and what are some strategies that have been developed to overcome this problem in treating various ailments?

 

MPI2.14: What drives the mutation/genetic variation in budding yeast?

 

MPI2.15: What is a compound that can be found in everyday life but causes DNA damage? And how do cells repair the damage on DNA?

 

MPI2.16: Which behavioural change theories can we use to form the basis of interventions for increasing physical activity in adults? How can we effectively deliver these interventions?

 

MPI2.17: What factors influence variability in physical activity behaviour? How can interventions address these factors?

 

MPI2.18: E3 ligase systems are important in regulating normal cellular function, but are often mutated in cancer. How do these mutations affect the role of the E3 ligase system, and how might they be targeted therapeutically?

 

MPI2.19: Loss of cell cycle control is a hallmark of cancer progression, but mutations in several different pathways can lead to cell cycle dysfunction. Which pathways are the most commonly mutated? Are there viable therapeutic options for these cancers?

 

MPI2.20: To what extent is the nucleus reuniens involved in the memory generalization?

 

MPI2.21: To what extent does epigenetics affect memory formation?

 

MPI2.22: How does exercise affect memory retention?

 

MPI2.23: There are many behavioral hallmarks of early Alzheimer’s Disease. What are some of the hallmarks and related brain structures that contribute to this?

 

MPI2.24: There are many neural biomarkers of early Alzheimer’s disease using immunohistochemistry staining. What do they indicate and what are the implications for this? (Eg: Stain for ____ (neural biomarker) showed ______, which indicates _____, implying that ______.)