12th Mentored Paper (Summer 2024)

Topics

MPI 12.1: How does nutritional status affect surgical outcomes of bariatric surgery?

 

MPI 12.2: How can artificial intelligence be used in nutritional sciences/ clinical nutrition to inform public health?

 

MPI 12.3: The mismatch negativity (MMN) is an early, preconscious neural marker of change detection commonly recorded using EEG/MEG, and has been proposed to be an indicator for early dementia (i.e., mild cognitive impairment) and Alzheimer's disease. A) What is the consensus of the literature on how the MMN changes in people with mild cognitive impairment and/or Alzheimer's disease, or B) how can we use this marker to inform clinical interventions in older adults     

 

MPI 12.4: Why are volatile organic compounds relevant in diagnostics and why does specificity matter?

 

MPI 12.5: Review of architecture and mechanism of non-invasive wearable biosensors

 

MPI 12.6: Review of fungi and mycotoxin detection in agricultural products: Mechanisms and device design.

 

MPI 12.7: Literature review: What is the role of DNA methylation in regulating the adaptation of skeletal muscle to exercise?

 

MPI 12.8: Literature review: How do satellite cells contribute to skeletal muscle angiogenesis in physiological and pathological contexts?

 

MPI 12.9: What is the epigenetic role of MDM2? 

 

MPI 12.10: How does exercise influence the adipose tissue?

 

MPI 12.11: How do epigenetic changes affect differentiation during hematopoiesis?  How can these processes be targeted for the treatment of AML?

 

MPI 12.12: How does transcription factor dysregulation result in leukemogenesis? How does this apply to pre-leukemic stem cells?

 

MPI 12.13: What are the differences in vaginal microbiome composition between premenopausal and postmenopausal women, and what are their implications on overall vaginal health?

 

MPI 12.14: How does the gut microbiome contribute to diabetes development?

 

MPI 12.15: How do macrophages contribute to metabolic diseases and are these cells suitable therapeutic targets? (Can be a literature review or research proposal on targeting macrophages to combat a particular metabolic disease)

 

MPI 12.16: Clearance of senescent β-cells to prevent diabetes progression: should we eliminate the cells most therapeutic approaches aim to preserve?

 

MPI 12.17: What are the gaps in tools/services for adolescent and young adult high grade gliomas patients?

 

MPI 12.18: How can we use nanocomposite materials in Military and infantry applications where we wish to be sustainable and also efficient at the same time? The application can be subjected to high temperatures, pressure, various forces, etc.

 

MPI 12.19: Can Pandemic-centric 3D printing become a mainstream technique in various industries by identifying areas where it can replace traditional methods, such as in medicine and agriculture, while also exploring sustainability aspects?

 

MPI 12.20: Developments in nanomaterials for biomedical applications, like bandages for covering wounds, postoperative regimens or biosensing.

 

MPI 12.21: Can we use kitchen waste fibres like fruit or vegetable peels) for high-strength metallic composite in regularly used applications (household, automotive, chemical, or medical) to ensure sustainability?

 

MPI 12.22: What are the mechanisms of circulating tumour DNA release?

 

MPI 12.23: What are the major hallmarks and characteristics of cancer?

 

MPI 12.24: How can machine learning be used to identify tissue of origin using genome-wide mutation features?

 

MPI 12.25: Studies on plakoglobin function in the context of cancer have been conflicting, with some labeling it as an oncogene, and others as a tumor suppressor. Discuss the roles of plakoglobin in tumorigenesis and tumor suppression.

 

MPI 12.26: APOBEC3A is a cytidine deaminase that functions in the innate immune system. What are the deaminase dependent and independent means by which it has been implicated in cancer?

 

MPI 12.27: Efforts to generate models that stably express APOBEC3B to study its function and role in cancer have been challenging. Discuss the possible reasons for this, as well as the approach(es) used to overcome this issue.

 

MPI 12.28: In the context of breast cancer, what is the mechanistic association between KMT2C/MLL3, a histone methyltransferase that is frequently subjected to loss-of-function mutations, and the development of hormone resistance during therapeutic interventions.

 

MPI 12.29: What is the role of Gamma-catenin in breast cancer initiation, progression, and metastasis, and are there potential interactions between Gamma-catenin and its homolog, Beta-catenin?

 

MPI 12.30: Describe the role of CUX1 as a tumor suppressor gene as well as an oncogene in breast cancer?

 

MPI 12.31: How do the mitochondria contribute to metabolic syndrome?

 

MPI 12.32: How does race influence an individual's risk of cardiovascular disease?

 

MPI 12.33: Why are infections involving multiple resistant bacteria hard to treat?

 

MPI 12.34: What bacterial traits allow antibiotic resistance to spread so quickly?

 

MPI 12.35: What are the underlying pathophysiological conditions in the lungs of Cystic Fibrosis patients that easily allow for bacterial infections that are hard to clear?

 

MPI 12.36: The auditory brainstem (superior olivary complex) has a tonotopic arrangement that converges signal from both ears. How does this auditory brainstem circuit structurally and functionally refine?

 

MPI 12.37: Immune checkpoint inhibitors have revolutionized how physicians treat cancer. How do immune co-stimulatory/co-inhibitory molecules balance immune responses. How do immune checkpoint inhibitors “re-start” the immune response against cancer?

 

MPI 12.38: How does synaptic plasticity contribute to the development of learning and memory functions during critical periods of cognitive development?

 

MPI 12.39: How do impairments in synaptic plasticity contribute to the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease, affecting learning and memory?

 

MPI 12.40: Which in vitro and in vivo models are currently available for studying Bronchopulmonary Dysplasia?

 

MPI 12.41: What is known about the molecular mechanism behind Pulmonary Hypertension pathogenesis?

 

MPI 12.42: What is the molecular mechanism behind prenatal lung development?

 

MPI 12.43: What is most important to families of children who die in critical care environments around the time of death?

 

MPI 12.44: What barriers do health care providers face in providing quality end of life care to children in critical care environments?

 

MPI 12.45: How do child-rearing values in individualistic and collectivist cultures impact rates of peripartum depression?

 

MPI 12.46: What is the impact of cortisol-linkage during pregnancy on paternal PPD?

 

MPI 12.47: What is the impact of DBT-M on executive functioning in adolescent girls with Borderline Personality Disorder?

 

MPI 12.48: How can inflammation during pregnancy contribute to cancer risk in pediatric populations?

 

MPI 12.49: How are important developmental pathways altered by the oxidative state of cells throughout development?

 

MPI 12.50: What are the implications of mitochondrial dysfunction in normal neurodevelopment and the connection to neurodevelopmental disorders?

 

MPI 12.51: How do extracellular vesicles influence inflammation in the tumour microenvironment of pediatric cancers?

 

MPI 12.52: What is the current knowledge on liquid biopsies for soft tissue cancers?

 

MPI 12.53: How could proteomics be used to augment personalized medicine or liquid biopsies for pediatric cancers?

 

MPI 12.54: What makes childhood cancer different from adult cancer?

 

MPI 12.55: How do liquid biopsy techniques improve cancer detection, diagnosis, and treatment?

 

MPI 12.56: How do marginalized youth in Canada navigate mental health barriers, and in what ways do cultural contexts and gender differences influence the accessibility of mental health services?

 

MPI 12.57: How do experiences of maternal health care differ between Indigenous and non-Indigenous women in Canada, and what are the implications for health outcomes and healthcare delivery?

 

MPI 12.58: How do nurse-family care programs address the needs and challenges faced by vulnerable mothers in Canada, and how effective are these programs in improving maternal and child health outcomes?

 

MPI 12.59: In recent years, plant immunity research has been largely focusing on the complex roles of the plant phytohormone salicylic acid, and defense metabolite N-hydroxypipecolic acid, in activating plant immune responses to pathogens. How may these new details about how the plant immune system protects plants from pathogenic disease be applied to help better protect crop plants in practice?

 

MPI 12.60: Plant biologists think a molecule important for plant immunity, N-hydroxypipeolic acid (NHP), might move from infected leaves to uninfected leaves to help activate resistance to potential future infections in these leaves. If so, this could be really important for designing methods to increase the resistance of agricultural crops to disease. Design experiments that would clarify if NHP really is a mobile defense signal capable of moving from one leaf to another.