10th Mentored Paper (Fall 2023)

Topics

MPI 10.1: What are the nutritional implications of bariatric surgery?

 

MPI 10.2: What is the relationship between dietary patterns and gut microbiota following a bariatric surgery?

 

MPI 10.3: What is the role of VEGF-A in influencing the epigenetic regulation of endothelial cell genes? (literature review)

 

MPI 10.4: Angiogenesis, established dogma and new perspectives. (Literature Review).

 

MPI 10.5: What is synthetic lethality? How can it be used to treat cancer?

 

MPI 10.6: According to the Canadian Paediatric Society childhood obesity rates have increased about 26% over the last 25 years. Please discuss the implications of obesity on the future health of children and what (if any) programs have been shown to improve clinical outcomes.

 

MPI 10.7: DNA repair is an important mechanism for the maintenance of genomic integrity and prevention of aberrant mutations leading to cancer. What are the mechanisms involved in the recognition, processing and regulation of DNA repair mechanisms? *

 

MPI 10.8: How do epigenetic changes affect differentiation during hematopoiesis?

 

MPI 10.9: How does transcription factor dysregulation result in leukemogenesis? How does this apply to pre-leukemic stem cells?

 

MPI 10.10: How does the bone marrow microenvironment support leukemia? And does it play a role in measurable residual disease (MRD)?

 

MPI 10.11: What is the role of macrophages in cancer progression and anti-tumour immune responses?

 

MPI 10.12: The use of deep learning and artificial intelligence in the detection of disease progression, specifically in bone and joint diseases

 

MPI 10.13: What advances in prosthetic design have improved the quality of life of patients requiring joint replacements? (They can focus on any one joint, i.e. knee, hip, shoulder, etc.)

 

MPI 10.14: How have advances in medical imaging impacted/improved osteoarthritis patient care?

 

MPI 10.15: To what extent collagen is being used in skin tissue engineering? How can the existing collagen scaffolds be optimised?

 

MPI 10.16: What are the collagen-based skin substitutes that passed the clinical trial stage and are being produced in large scale?

 

MPI 10.17: How have ethical principles been incorporated in the development of healthcare prioritization strategies or policies?

 

MPI 10.18: What criteria has been used to develop prioritization policies or strategies in healthcare?

 

MPI 10.19: What methods have been used to assess the impact of different prioritization strategies for waitlists of health interventions?

 

MPI 10.20: What are the most effective waitlist management strategies in healthcare?

 

MPI 10.21: What is the epigenetic role of MDM2?

 

MPI 10.22: How does exercise influence the adipose tissue?

 

MPI 10.23: What is the effect of rhythmic stabilizations on gait training in individuals with multiple sclerosis? (literature review)

 

MPI 10.24: What’s the bone healing procedure around the dental peri-implant region?

 

MPI 10.25: What are the current methodologies to prevent peri-implantitis?

 

MPI 10.26: What’s the limitation of the current local delivery system around the peri-implant region?

 

MPI 10.27: Is there evidence for neurological symptoms following COVID-19 infection?

 

MPI 10.28: The role of the innate and/or adaptive immune responses in neurodegeneration/neurodegenerative diseases (one cell type or many)

 

MPI 10.29: What are some current therapies or potential therapies that can be used for targeting T cell-mediated autoimmunity?

 

MPI 10.30: How can neuromodulation techniques be used in instances of treatment resistant psychiatric disorders?

 

MPI 10.31: What are the hypothesized mechanisms by which repetitive transcranial magnetic stimulation (rTMS) improves depression symptoms?

 

MPI 10.32: What are the current challenges in biomarker discovery for major depressive disorder?

 

MPI 10.33: What are tooth-derived stem cells?

 

MPI 10.34: What are the properties of an ideal scaffold for bone regeneration purposes?

 

MPI 10.35: What is the relationship between food insecurity and mental health outcomes?

 

MPI 10.36: How does the climate crisis (and related climate anxiety) impact people's mental health?

 

MPI 10.37: What are the short and long-term psychological impacts of being adopted?

 

MPI 10.38: What advantages does the vaccine therapy provide for cancer treatment? Review its current development process.

 

MPI 10.39: What limits the application and efficacy of CAR-T (CAR-T means Chimeric Artificial T cell Receptor) therapy, and how to solve these problems?

 

MPI 10.40: What advantages and potential of induced pluripotent stem cells in clinical therapy?

 

MPI 10.41: What are the immune mechanisms underlying HIV infection risk and susceptibility during a Candida infection (yeast infection)?

 

MPI 10.42: What role does gut-brain-immune function play in the neurobiology of depression?

 

MPI 10.43: Can alterations in functional brain connectivity serve as a biomarker in the prediction of suicide risk?

 

MPI 10.44: How do markers of psychological and/or physical pain influence suicide risk?

 

MPI 10.45: Describe the relationship between clonal hematopoiesis and cardiovascular disease states.

 

MPI 10.46: How can extracellular vesicles be used as drug delivery vehicles?

 

MPI 10.47: How does aging affect our gut microbiome composition? Could this contribute to age-related disease states?

 

MPI 10.48: How do macrophages contribute to metabolic diseases and are these cells suitable therapeutic targets? (Can be a literature review or research proposal on targeting macrophages to combat a particular metabolic disease)

 

MPI 10.49: Clearance of senescent β-cells to prevent diabetes progression: should we eliminate the cells most therapeutic approaches aim to preserve?

 

MPI 10.50: Can our current knowledge of psilocybin’s pharmacokinetics help predict maternal psilocybin use on placental development?

 

MPI 10.51: What factors contribute to the development of cognitive impairments after surgery, and what are some potential mechanisms?

 

MPI 10.52: How does tonic inhibition in the hippocampus regulate synaptic plasticity?

 

MPI 10.53: What recent innovations in CRISPR expand its use and applicability?

 

MPI 10.54: What effects do different bacterial strains in the gut microbiome have on human health and disease?

 

MPI 10.55: What are the challenges of heart regeneration? What advances have addressed these issues and how can they be optimized?

 

MPI 10.56: What are the potential uses of exosomes in tendon healing or cancer research?’

 

MPI 10.57: What are some tested methods for reducing wait list times for elective cardiac surgery?

 

MPI 10.58: What are some of the pre-operative determinants of poor adverse effects after surgery?

 

MPI 10.59: Is the cytoskeleton important in DNA damage repair?

 

MPI 10.60: Where do we stand in targeted therapy against BRCA1/2 deficient cancers?

 

MPI 10.61: Why is it so challenging to identify and treat autoimmune diseases? What are some current approaches being used? [For this question, it is possible to focus on a specific autoimmune disease or be more broad]

 

MPI 10.62: Platelets are small cellular fragments essential for vessel occlusion. Lately, platelets are increasingly recognized for their roles in modulating immune/cancer cells, and thus, a potential therapeutic target for certain diseases. Can you think about the advantages and disadvantages for this?

 

MPI 10.63: The use of animal models in research has often been criticized. Do you think researchers are justified in using animal models in their research?